Over the past decades, synchrotron X-rays have open new avenues in biomedical research. The high degree of coherence and brilliance of synchrotron beams have made possible to reach unprecedented level of detail in the investigation of biological tissues through the application of advanced experimental techniques in in-vitro and in-vivo models. Ex-vivo studies allow optimizing experimental...
High spatial resolution correlative imaging approaches are needed to understand structure-function relationships in cell biology. These correlative approaches are particularly challenging for the study of biologically active metals in synapses due to (i) the labile binding of these elements, (ii) the nanoscale size of synaptic structures; (iii) the low concentrations of these elements. We...
Recent advances in hard X-ray microscopy make possible reaching new levels of resolving power in thick biological samples. Thanks to high brilliance coherent beams combined with cutting-edge nano-focusing optics and high precision tomographic scanning, X-ray holography can probe the 3D structure of up to millimeter sized tissues at tens of nanometers spatial resolution. This opens new horizons...
X-ray imaging scans at today's synchrotron light sources can yield thousands of image frames per second at high resolution. Current and expected data volumes and rates necessitate having reliable, efficient, and fully automated data processing pipelines. Traditional image processes are difficult to be modeled and are not robust enough for the data with complex patterns and noises. Deep...
Over the last years, we have worked towards developing methods to fabricate and characterize three-dimensional magnetic structures. Specifically, we have combined X-ray magnetic imaging with new iterative reconstruction algorithms to achieve X-ray magnetic tomography and laminography [1-4]. In a first demonstration, we have determined the three-dimensional magnetic nanostructure within the...
