Conveners
Session 6 - II ALBA User's Meeting 2015
- Miguel A. G. Aranda (ALBA-CELLS)
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18/06/2015, 09:00
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18/06/2015, 09:20
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18/06/2015, 09:40
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Dr Rafael Molina (CNIO)18/06/2015, 10:00II ALBA User's MeetingOral presentationsThe enzymatic hydrolysis of DNA phosphodiester bonds has been widely studied, but the chemical reaction has not yet been observed. Here we follow the generation of a DNA double-strand break (DSB) by the Desulfurococcus mobilis homing endonuclease I-DmoI, trapping sequential stages of a two-metal-ion cleavage mechanism. We captured intermediates of the different catalytic steps, and this...Go to contribution page
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Rafael Junqueira Borges (IBMB-CSIC, UNESP)18/06/2015, 10:20II ALBA User's MeetingOral presentationsPhasing your XALOC data with ARCIMBOLDO Macromolecular Ab Initio phasing, from the native intensities alone with no experimental phase information or previous particular structural knowledge has been the object of a long quest, limited by two main barriers: structure size and data resolution. Beyond the first atomic resolution successes, current approaches have been developed, exploiting...Go to contribution page
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Prof. Daniela Uhrikova (Faculty of Pharmacy, Comenius University in Bratislava)18/06/2015, 10:40II ALBA User's MeetingOral presentationsDNA polyanion interacts with a dispersion of cationic liposomes forming supramolecular assemblies of regular inner microstructure – lipoplexes. They are studied as delivery vectors for genetic material. Despite the fact that cationic liposomes have been used for transfection, and commercial lipid formulations are available, their efficiency needs to be improved. We will discuss structural...Go to contribution page