Conveners
ALBA A - 08/09/22 II
- Judith Juanhuix Gibert
Phase-contrast X-ray imaging uses the refraction of X-rays to generate the contrast. It has been demonstrated to provide superior soft-tissue contrast in comparison to conventional attenuation-based X-ray imaging. However, quantitative imaging of biomedical soft tissue at high spatial resolution and high image quality still remains challenging. Some existing methods require assumptions on the...
Our aim was to apply high resolution and precision techniques to investigate the efficacy of gene editing to revert the cellular and biochemical phenotype of cells harbouring collagen VI mutations which give raise to a severe form of Muscular Dystrophy. Soft X-ray tomography can provide new structural and complementary results given that no sectioning is required, thus preserving the...
Cardiomyopathies are serious heart muscle (myocardial) abnormalities which can lead to life-threatening complications such as heart failure, cardiac arrest, and sudden death. Myocardial biopsies obtained from surgical septal myectomies are essential for confirming diagnosis of cardiomyopathies. Owing to the recent advancements of synchrotron radiation-based X-ray phase contrast imaging (XPCI),...
Microtubules (MTs) are dynamic filaments involved in many essential cellular functions including those needed for cancer cell growth. Taxanes are MT stabilizing agents and the most successful antitumoral drugs targeting MTs. However, despite their mode of action is the stabilization (i.e., do not destroy the filament structure), they produce a paradoxical neurotoxic effect by inducing axon...
