Conveners
ALBA A - 08/09/22 I
- Olga Lopez (IQAC-CSIC)
The Life Sciences scientific program at the ALBA synchrotron has been well established for years, with several beamlines covering multiple techniques widely used in structural molecular and cellular biology. Still, as part of the future ALBA-II upgrade, the program is being further developed to offer new techniques. The existing beamlines are planned to undergo throughout upgrades in the...
In the new Alphafold2 era, the interest of structural biologists on macromolecular dynamics has increased. Synchrotron Serial Crystallography (SSX) may still be not so known among crystallographers as single-crystal MX, however, the serial data collection of multiple non cryocooled microcrystals opens the door not only to projects including radiation sensitive targets (as metalloproteins) or...
The new Cryo-electron Microscope Platform possess a specialized cryo-electron microscope for structural biology applications, equipped with an automated sample load system and a last generation direct electron detector Falcon IV. The platform will give access to state-of-the-art cryo-EM equipment for structure determination projects using the latest technology and methods.
This equipment will...
Owing to the importance of the SAD technique, |ρ|-based direct methods in the form of the recent SMAR (= SM,|ρ|) phasing algorithm incorporating the inner-pixel-preservation (ipp) procedure [Rius, J.& Torrelles, X. (2021) Acta Cryst A77, 489-493] have been adapted to the determination of anomalous scatterers substructures. Their applicability has been tested on a series of...
We have used SAXS to investigate the incorporation of several peptide amphiphiles to vesicles. These modified peptides have been shown to have amphiphilic properties. Vesicles have distinct SAXS features that provide information about the electronic density across the bilayer. We have adopted a multiple Gaussian description of the bilayers using several constrains to keep the number of fitting...
