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Amyloid peptides are the main component of one of the characteristic pathological hallmarks of Alzheimer's disease (AD): senile plaques. According to the amyloid cascade hypothesis, amyloid peptides may play a central role in the sequence of events that leads to neurodegeneration. However, there are other factors, such as oxidative stress, that may be crucial for the development of the disease. We proved that using Fourier Transform Infrared Microscopy is it possible to co-localize amyloid deposits and lipids oxidation in tissue slides from patients affected by Alzheimer's disease.