The metabolic activity of T cells involves the control of cellular proteostasis, including gene transcription, protein translation, de novo protein folding, post-translational modifications, secretion, degradation and recycling. Some of these steps are regulated by the chaperonin complex CCT, which is involved in the correct folding of certain proteins. By limiting CCT levels with siRNA in...
Portland cements are environmentally contentious, accounting for ≈7% of anthropogenic CO2 emissions. If cement production is considered a country, it would be the third emitter just after China and USA. Hence, developing concretes with lower embodied carbon contents is central to maintaining our well-being. The main drawback of the most ambitious proposals for sustainable low-carbon cements is...
Three-dimensional nanomagnetic systems, featuring novel and unconventional spin textures, offer an exciting platform to explore new magnetic phenomena, and also offers possibilities for the development of more efficient, capable and multifunctional technologies. However, harnessing these effects requires an understanding of the fundamental properties and behaviour.
The experimental study of...
Drug development relies on a thorough understanding of the structural parameters governing drug/target interactions and the structural effects resulting from drug binding in the target structure. The Unit for the Development of New Chemical, Biological, and Immunological Drugs aims (among other targets) to design and optimize compounds targeting microtubules, essential cellular polymers...
The last decade witnessed rapid development in data science and machine learning (ML) methods, which are finding more and more applications across diverse fields, and make a dramatic impact also on the processing of spectroscopic data. In particular, the application of unsupervised and supervised ML methods provides new opportunities for detecting subtle fingerprints of structural changes in...
Integrating physiology and structure at the neuronal circuit scale can provide a mechanistic understanding on how that circuit works. The glomerular columns in the mouse olfactory bulb contain the first synapse of the olfactory sensory pathway, through a circuit that is compact, modular and accessible to optophysiology setups. A correlative multimodal imaging pipeline that combines in vivo...
Commercial like catalysts are very complex systems due to the interplay of different parameters which complicate the understanding of the active site. To this we have to add the dynamic behaviour of the catalyst as well as possible structural catalyst modifications due to reaction conditions which may take place at the surface or even at the subsurface or bulk level of the catalyst influencing...
